The Correlation Between Helicobacter Pylori infection and Lipid Profile in Bushehr Healthy Heart Study

مولایی منش, زهرا and نبی پور, ایرج and وحدت, کتایون (2013) The Correlation Between Helicobacter Pylori infection and Lipid Profile in Bushehr Healthy Heart Study. Other thesis, دانشگاه علوم پزشکی و خدمات بهداشتی درمانی بوشهر.


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Introduction: Helicobacter pylori(H.pylori) is the most common infection throughout the world, with a higher prevalence in developing contries.This infection is reported to be associated with many extragastrointestinal diseases, such as cardiovascular disease. Among the studies that have suggested a relationship between H.pylori infection and coronary heart disease, some of the underlying mechanisms still need to be discovered. It has been reported that chronic H.pylori infection results in lipid alterations that could partially contribute to the initiation and development of coronary atherosclerosis.This study is design to investigate the correlation of H.pylori seropositivity and lipid profile in a cross sectional population based study. Methods: We selected 1754 patients( 50.8 % females, 49.2 % males),older than 25 year old , randomly from MONICA Healthy Heart project. Sera were screened for IgG antibobies against H.pylori with an ELISA and the samples were considered positive with IgG values higher than 30 RU/ml. Result: The prevalence of H.pylori seropositivity was 61.57% in the studied population. At first there was a correlation between H.pylori and decreased HDL-c (P = 0.042)and increased TG (P = 0.01) in primary unadjusted analysis, however, after age and sex adjustment only association between H.pylori and decreased HDL-c remained significant (P = 0.040 ; OR=1.23, 95%CI: 1.0-1.50).But at the end multiple logistic regression analysis showed no more correlation between H.pylori seropositivity and HDL-c & other lipid profiles. Conclusion: In this large population based study that was designed in Northern Persian Gulf cities , no correlation between H.pylori infection and lipid profile demonstrated among men and women.

Item Type: Thesis (Other)
Uncontrolled Keywords: Key Words: H.pylori, atherosclerosis, HDL-cholestrol, LDL-cholestrol, dyslipidemia, cardiovascular disease, metabolic syndrome
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicin
Depositing User: محسن زارعی
Date Deposited: 17 Aug 2014 05:07
Last Modified: 17 Aug 2014 07:36

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