Zarsanj, Narjes and Salimipour, Hooman and Kalantar Hormozi, Mohamadreza and Motamed, Niloufar (2011) Comparison of efficacy and tolerability of Duloxetine vs. Gabapentin in treatment of diabetic peripheral neuropathic pain. Other thesis, Bushehr University of Medical Sciences.
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Abstract
Introduction: Diabetic peripheral neuropathy (DPN) is one of the most common symptomatic, long-term complications in patients with both type 1 and type 2 diabetes mellitus, and most common and most debilitating of the diabetic neuropathies. Duloxetine, a selective serotonin norepinephrine reuptake inhibitor (SNRI), is effective for the treatment of painful diabetic polyneuropathy. The most common reported side effects of duloxetine are nausea, somnolence, dizziness, decreased appetite, and constipation. Gabapentin is an anticonvulsant effective in peripheral diabetic neuropathic pain. Side effects include dizziness, sedation and weight gain. Methods: We selected 60 diabetic patients, with peripheral diabetic neuropathic pain, including of 33 men (mean age=43 years), and 27 women (mean age=42 years). Of these 60 patients 43 patients had been treated with gabapentin and had an inadequate response after at least 3months of treatment, and 17 patients had been complicated with side effects before reaching full dose of Gabapentin. We started Duloxetine 60mg once daily and evaluated the patients� pain improvement after 3months. Results: Mean pain score was 6.21 before starting Gabapentin, 5.28 after 3months treatment with Gabapentin, and 4.61 after 3months treatment with Duloxetine (P value=0.000). Checking HbA1C before and after treatment with Duloxetine showed significant decrease, but checking blood pressure before and after treatment with Duloxetine showed no significant change. Conclusion: Duloxetine with dose of 60 mg once daily is effective and tolerable for diabetic patients with peripheral diabetic neuropathic pain.
| Item Type: | Thesis (Other) |
|---|---|
| Uncontrolled Keywords: | Diabetic peripheral neuropathic pain; Diabetes; Duloxetine; selective serotonin norepinephrine reuptake inhibitor |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicin |
| Depositing User: | سیده سمیه موسوی نژاد |
| Date Deposited: | 17 Aug 2014 07:04 |
| Last Modified: | 27 Aug 2014 10:00 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/404 |
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