Novel renoprotection methods by local and remote conditioning

Kadkhodaee, Mehri and Sedaghat, Zahra (2013) Novel renoprotection methods by local and remote conditioning. Journal of Renal Injury Prevention, 3 (2). pp. 37-38.


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Implication for health policy/practice/research/medical education: The possibility to create resistance against ischemic injury through ‘organ conditioning’ is an area of increasing interest. The remote ischemic conditioning may have an immense effect on the renal patients and in clinical practice in the near future. Remote ischemic per-conditioning is perhaps the most promising protective strategy among the adaptive surgical techniques. By far, no integral treatment is available to improve outcomes in patients encountering renal ischemia-reperfusion injury (IRI), when blood supply to the kidney is interrupted and then restored. IRI occurs in a broad spectrum of clinical settings, including surgery, trauma or sepsis that leads to the functional disturbances of the kidneys. During transplantation, IRI is a risk factor for delayed graft function, which prolongs hospitalization and increases the cost. However, in recent years, ischemic conditioning methods have been discussed as powerful protective techniques to reduce the extent of renal IRI. These novel approaches have shown promising results in animals and research are underway to examine their exact effect in human in the clinical scenarios.

Item Type: Article
Additional Information: indexer:samaneh vafadar
Uncontrolled Keywords: Ischemia-reperfusion Ischemic conditioning Renoprotection
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicin
Depositing User: Unnamed user with username karvarz1
Date Deposited: 19 Dec 2015 18:36
Last Modified: 19 Dec 2015 18:36

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