Relationship among dietary estimates of net endogenous acid production, bone mineral density and biochemical markers of bone turnover in an Iranian general population

Rahbar, Alireza and Larijani, Bagher and Nabipour, Iraj and Mohamadi, Mohamad Mehdi and Mirzaee, Kamran and Amiri, Zahra (2009) Relationship among dietary estimates of net endogenous acid production, bone mineral density and biochemical markers of bone turnover in an Iranian general population. Bone, 45 (5).

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed

Abstract

Chronic, low-grade metabolic acidosis due toWestern diets may be a risk factor for osteoporosis. The severity can be determined in part by net endogenous acid production (NEAP). In a population-based study, a total of 1028 healthy men and women aged 20–72 years were evaluated for dietary intakes and NEAP estimates with a validated food frequency questionnaire. Dual-energy X-ray absorptiometry (DXA) was used to determine BMD of the lumbar spine (L2–L4), distal third of radius, and proximal femur. Serum CrossLaps, degradation products of the C-terminal telopeptides of type I collagen, and osteocalcin were measured by highly specific ELISA methods. Lower estimates of energy-adjusted rates of NEAP were associated with greater femoral neck BMD (p=0.01) in premenopausal women and with greater BMDs at the distal radius (p=0.001) and lumbar spine (p=0.04) in postmenopausal women. Compared with women in the highest quartile of the estimates of the energy-adjusted rates of NEAP, pre- and postmenopausal women in the lowest quartile had significantly greater means of osteocalcin [9.12 (SD±1.62) vs. 5.24 (SD±1.41) ng/ml, p=0.02 and 11.74 (SD±1.69) vs. 7.79 (SD±2.63) ng/ml, p=0.002, respectively]. Analysis by quartiles of the estimates of energy-adjusted rates of NEAP did not reveal a relationship between BMD and bone turnover markers in men. In conclusion, we found that a high energy-adjusted rate of NEAP was associated with a significantly lower BMD in women but not in men and the energy-adjusted rate of NEAP had a negative relationship with bone formation.

Item Type: Article
Additional Information: indexer : farshid rvansalar
Uncontrolled Keywords: Net endogenous acid production (NEAP) Dietary potassium Bone mineral density Bone turnover markers Osteoporosis
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Dentistry
Depositing User: Unnamed user with username karvarz1
Date Deposited: 19 Dec 2015 18:42
Last Modified: 19 Dec 2015 18:42
URI: http://eprints.bpums.ac.ir/id/eprint/4369

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