Leukemia and small round blue-cell tumor cancer detection using microarray gene expression data set: Combining data dimension reduction and variable selection technique

Karimi, Sadegh and Farrokhnia, Maryam (2014) Leukemia and small round blue-cell tumor cancer detection using microarray gene expression data set: Combining data dimension reduction and variable selection technique. Chemometrics and Intelligent Laboratory Systems, 139.

[img]
Preview
Text
67.pdf

Download (618kB) | Preview
Official URL: http://www.sciencedirect.com/

Abstract

Using gene expression data in cancer classification plays an important role for solving the fundamental problems relating to cancer diagnosis. Because of high throughput of gene expression data for healthy and patient samples, a variable selection method can be applied to reduce complexity of the model and improve the classification performance. Since variable selection procedures pose a risk of over-fitting, when a large number of variables with respect to sample are used,we have proposed a method for coupling data dimension reduction and variable selection in the present study. This approach uses the concept of variable clustering for the original data set. Significant components of local principal component analysis models have just been retained from all clusters. Then, the variable selection algorithm is performed on these locally derived principal component variables. The proposed algorithm has been evaluated on two gene expression data sets; namely, acute Leukemia and small round blue-cell tumor (SRBCT). Our results confirmed that the classification models achieved on the reduced data were better than those obtained on the entire microarray gene expression profile.

Item Type: Article
Additional Information: indexer :farshid ravansalar
Uncontrolled Keywords: Microarray gene expression Linear discriminant analysis Clustering of variable Kohonen self-organizing map Genetic algorithm
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Dentistry
Depositing User: Unnamed user with username karvarz1
Date Deposited: 19 Dec 2015 18:42
Last Modified: 19 Dec 2015 18:42
URI: http://eprints.bpums.ac.ir/id/eprint/4370

Actions (login required)

View Item View Item