High sensitivity C-reactive protein is associated with the metabolic syndrome independent to viral and bacterial pathogen burden

Ebrahimi,, Abdolali and Nabipour, Iraj and Vahdat,, Katayoun and Jafari,, Seyed Mojtaba and Fouladvand,, Moradali and Assadi,, Majid and Movahed,, Ali and Obeidi,, Narges and Sanjdideh, Zahra (2009) High sensitivity C-reactive protein is associated with the metabolic syndrome independent to viral and bacterial pathogen burden. Diabetes Res Clin Pract, 84 (3).

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed

Abstract

To investigate the influences of bacterial or viral pathogen burden in the relationship of high sensitivity C-reactive protein (hs-CRP) and the metabolic syndrome in a population-based study. METHODS: Data from 1754 men and women aged >or=25 years, from the Persian Gulf Healthy Heart Study were analyzed. The definition of the metabolic syndrome according to the Adult Treatment Panel III was used. Sera were analyzed for IgG antibodies to Chlamydia pneumoniae, Herpes simplex virus type 1, Helicobacter pylori and cytomegalovirus using ELISA. Measurement of CRP by a high-sensitivity CRP assay was done. RESULTS: The subjects with the metabolic syndrome had a higher geometric mean of CRP levels than the normal persons (p<0.0001). A linear relationship between an increase in the number of metabolic syndrome components and CRP concentrations was observed (p for trend<0.0001). In multiple logistic regression models, hs-CRP showed significant associations with the metabolic syndrome after controlling for cardiovascular risk factors and infectious burden divided into 2, 3 and 4 pathogens [OR=2.06, CI (1.32-3.21), p=0.001; OR=1.75, CI (1.26-2.42), p=0. 001; OR=2.12, CI (1.46-3.08), p<0.0001; respectively].

Item Type: Article
Additional Information: indexer :farshid ravansalar
Uncontrolled Keywords: C-reactive protein Metabolic Pathogen burden Insulin resistance Inflammation
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Dentistry
Depositing User: Unnamed user with username karvarz1
Date Deposited: 01 Feb 2016 11:51
Last Modified: 01 Feb 2016 11:51
URI: http://eprints.bpums.ac.ir/id/eprint/4380

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