99 mTc-MIBI washout as a complementary factor in the evaluation of idiopathic dilated cardiomyopathy (IDCM) using myocardial perfusion imaging

Shiroodi, Mohammad Kazem and Shafiei, Babak and Baharfard, Nastaran and Gheidari, Mohammad Esmail and Nazari, Babak and Pirayesh, Elaheh and Kiasat, Ali and Hoseinzadeh, Samaneh and Hashemi, Abolghassem and Akbarzadeh, Mohammad Ali and Javadi, Hamid and Nabipour, Iraj and Assadi, Majid (2012) 99 mTc-MIBI washout as a complementary factor in the evaluation of idiopathic dilated cardiomyopathy (IDCM) using myocardial perfusion imaging. Int J Cardiovasc Imaging, 28. pp. 211-217.

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Rapid technetium-99 m methoxyisobutylisonitrile (99 mTc-MIBI) washout has been shown to occur in impairedmyocardia. This study is based on the hypothesis that scintigraphy can be applied to calculate the myocardial 99 mTc-MIBI washout rate (WR) to diagnose and evaluate heart failure severity and other left ventricular functional parameters specifically in idiopathic dilated cardiomyopathy (IDCM) patients. Patients with IDCMP (n = 17; 52.65 ± 11.47 years) and normal subjects (n = 6; 49.67 ± 10.15 years)were intravenously administered 99 mTc-hexakis-2-methoxyisobutylisonitrile (99 mTc-MIBI). Next, early and delayed planar data were acquired (at 3.5-h intervals), and electrocardiogram (ECG)-gated myocardial perfusion single photon emission computed tomography (SPECT) was performed. The 99 mTc-MIBI WR was calculated using early and delayed planar images. Left ventricular functional parameters were also analyzed using quantitative gated SPECT (QGS) data. In target group, myocardial WRs (29.13 ± 6.68%) were significantly higher than those of control subjects (14.17 ± 3.31%; P\0.001). The 99 mTc-MIBI WR increased with the increasing severity of the NYHA functional class (23.16 ± 1.72% for class I, 30.25 ± 0.95%for class II, 32.60 ± 6.73%for class III, and 37.50 ± 7.77% for class IV; P = 0.02). The WR was positively correlated with the end-diastolic volume (EDV) index (r2 = 0.216; b = 0.464; P = 0.02 [ml/m2], the end-systolic volume (ESV) index (r2 = 0.234; b = 0.484; P = 0.01 [ml/m2]), the summed motion score (SMS) (r2 = 0.544; b = 0.738; P = 0.00), and the summed thickening score (STS) (r2 = 0.656; b = 0.810; P = 0.00); it was negatively correlated with the left ventricular ejection fraction (LVEF) (r2 = 0.679; b = –0.824; P = 0.00). It can be concluded that 99 mTc-MIBI scintigraphy might be a valuable molecular imaging tool for the diagnosis and evaluation of myocardial damage or dysfunction severity.

Item Type: Article
Additional Information: indexer:anis najafi
Uncontrolled Keywords: Washout rate � 99 mTc-sestamibi scintigraphy � Idiopathic dilated cardiomyopathy � Gated SPECT
Divisions: Faculty of Medicin
Depositing User: Unnamed user with username karvarz2
Date Deposited: 17 Jul 2016 03:10
Last Modified: 17 Jul 2016 03:10
URI: http://eprints.bpums.ac.ir/id/eprint/4424

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