Pathogenesis and Causes of Premature Ovarian Failure: An Update

Ebrahimi, Mahbod and Akbari Asbagh, Firoozeh (2011) Pathogenesis and Causes of Premature Ovarian Failure: An Update. International Journal of Fertility and Sterility, 5 (2). pp. 54-65.

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Premature ovarian failure (POF) affects 1% of young women. This condition has significant psychological sequelae and major health implications. POF seriously interferes with fertility and family planning. Diverse etiologies are associated with POF. Literature review related to the causes and pathogenesis of POF, cited between the year 1900 and May 2010. POF may be either spontaneous or induced. The known causes include: - Genetic disorders, which could involve the X chromosome or autosomes. However, the growing body of literature demonstrates a list of newly discovered mutations that may be responsible for causing POF. Most of these mutations are extremely rare, and most cases of POF are still considered to be idiopathic. - Autoimmune causes; there is some evidence of an association of POF with lymphocytic oophoritis and other autoimmune disorders. Antiovarian antibodies are reported in POF, but their specificity and pathogenic role are obscure. - Iatrogenic causes; chemotherapy, radiotherapy and pelvic surgery can lead to POF. - Infectious Causes; some viral and microbial infections can be followed by POF. - Environmental toxins, such as cigarette smoking are reported as risk factors of spontaneous POF. - Idiopathic; in most cases, no identifiable etiology can be recognized after complete evaluation

Item Type: Article
Additional Information: indexer:anis najafi
Uncontrolled Keywords: Premature Menopause, Premature Ovarian Failure, Hypergonadotropic Ovarian Failure, Hypergonadotropic Hypogonadism, Premature Ovarian Insufficiency
Divisions: Faculty of Medicin
Depositing User: Unnamed user with username karvarz2
Date Deposited: 17 Jul 2016 03:10
Last Modified: 17 Jul 2016 03:10

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