The Effect of Zinc Supplementation on Expressed Levels of Peroxisome Proliferator-Activated Receptor Gamma and Glucose Transporter Type 1 Genes in Newborns of Women with Gestational Diabetes Mellitus

Heidarzadeh, Zahra and Samimi, Mansooreh and Seifati, Seyed Morteza and Dehghani Ashkezari, Mahmood and Ahmadi, Shahnaz and Mahmoodi, Samaneh and Aghadavod, Esmat and Jamilian, Mehri and Asemi, Zatollah (2016) The Effect of Zinc Supplementation on Expressed Levels of Peroxisome Proliferator-Activated Receptor Gamma and Glucose Transporter Type 1 Genes in Newborns of Women with Gestational Diabetes Mellitus. Biol Trace Elem Res.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/27334434

Abstract

The current study was designed to determine the beneficial effects of zinc supplementation on expressed levels of peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 1 (GLUT1) genes in newborns of women with gestational diabetes mellitus (GDM). This randomized, double-blind, placebo-controlled clinical trial was performed among 40 women with GDM. Patients were randomly allocated to intake either 233 mg zinc gluconate (containing 30 mg zinc) (n = 20) or a placebo (n = 20) for 6 weeks. PPAR-γ and GLUT1 mRNA levels were quantified in umbilical cord blood of newborns of women with GDM. After 6 weeks of intervention, the change in serum zinc levels was greater in women consuming zinc than in the placebo group (+11.1 ± 13.4 vs. -4.8 ± 17.3 mg/dL, P = 0.002). Quantitative results of RT-PCR demonstrated that compared with the placebo, zinc supplementation resulted in a significant increase of expressed levels of PPAR-γ mRNA (P < 0.001) and GLUT1 mRNA (P < 0.001) in umbilical cord blood of newborns of women with GDM. Taken together, the current study demonstrated that zinc supplementation for 6 weeks among GDM women increased the mRNA levels of PPAR-γ and GLUT1 in their newborns compared with the placebo group.

Item Type: Article
Uncontrolled Keywords: Zinc . Supplementation . Gestational diabetes . Peroxisome proliferator-activated receptor gamma . Glucose transporter type 1
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Other Journals
Depositing User: سمیه باغبانی
Date Deposited: 06 Sep 2016 09:32
Last Modified: 06 Sep 2016 09:32
URI: http://eprints.bpums.ac.ir/id/eprint/5286

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