Maneshi, Hesam_oddin and Rahmani, Elham and Ahmadi, Shahnaz and Motamed, Niloofar (2012) Dosage Optimization for Letrozole Treatment in Clomiphene-Resistant Patients with Polycystic Ovary Syndrome: A Prospective Interventional Study. Other thesis, دانشگاه علوم پزشکی و خدمات بهداشتی درمانی بوشهر.
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Abstract
Objective: Dose adjustment for induction of ovulation is one of the most important problem. Methods: In a prospective interventional study, 44 clomiphene-resistant infertile patients (113 cycles) were selected from the Abolfazl Infertility Clinic of Bushehr University of Medical Sciences. Letrozole was given orally in a dose of 2.5 mg, 5 mg, and 7.5mg, respectively. If the patient displayed no response, the dosage was increased. Results: In these patients ovulation occurred in 50 cycles (44.24%), clinical pregnancy rate according to number of cycles was 23.89% (27 of 113 cycles) and according to the number of patients was 61.36% (27 of 44 patients). In the 2.5, 5, and 7.5 groups, follicles occurred in 22.9%, 42.1%, and 85.18% of cycles, and pregnancy rate was 14.58%, 28.94% and, 33.33%, respectively. Conclusions: It is better to administer Letrozole at a lower dosage to prevent complications and increase the dose based on sonographic results antral follicular count, anti-Mullerian hormone, LH/FSH, and estradiol.
| Item Type: | Thesis (Other) |
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| Uncontrolled Keywords: | infertility, letrozole, clomiphene citrate, polycystic ovary syndrome |
| Subjects: | R Medicine > RG Gynecology and obstetrics |
| Divisions: | Faculty of Medicin |
| Depositing User: | خدیجه شبانکاره |
| Date Deposited: | 20 Aug 2014 03:58 |
| Last Modified: | 20 Aug 2014 03:58 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/560 |
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