Final report of research project (thesis of medicaldegree)the determination of ubi scanin dete of ost eomye litis

Sehat, Mohamadreza and Katayun, Vahdat and Asadi, Majid (2007) Final report of research project (thesis of medicaldegree)the determination of ubi scanin dete of ost eomye litis. Other thesis, دانشگاه علوم پزشکی وخدمات بهداشتی درمانی بوشهر.

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ABSTRACT: Introduction: Imaging can be a useful tool in the setting of suspected osteomyelitis. Currently available techniques such as ultrasonography, CT, and MRI are anatomically oriented. Despite being highly sensitive and sophisticated, these modalities lack specificity for infection. Recently, antimicrobial peptides have been proposed as new agents to distinguish bacterial infections from sterile inflammatory processes and ubiquicidin (UBI) 29-41 is one of them that has showed interesting results for infection detection in previous studies. The aim of this study was to determine the UBI scan accuracy in detection of osteomyelitis and comparison of it with other modalities. Methods: Twenty patients (mean age=48.90 years) with suspected osteomyelitis were included in this study. After evaluation of each patient by history taking, physical exam, and proper laboratory tests, other processes include bone probing, wound culture, simple X-ray, bone MRI, and UBI scan were done for them. Preliminary diagnosis of osteomyelitis was acquired according to clinical and paraclinical data and confirmed by patient’s fallow up. Results: In current study, 17 cases had osteomyelitis in UBI scan and it showed accuracy of 100% in detection of osteomyelitis, compared with accuracy of 90% for three phase bone scan. Conclusion: 99mTc-UBI 29-41 is a proper choice for detection of osteomyelitis, regarding the fast imaging with high sensitivity, specificity, and accuracy. Key Words: Osteomyelitis; Ubiquicidin; 99mTc-UBI; Antimicrobial peptides; Infection detection

Item Type: Thesis (Other)
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicin
Depositing User: ریحانه فقیهیان
Date Deposited: 20 Aug 2014 10:14
Last Modified: 27 Aug 2014 10:01

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