Effect of Dipyridamole Injected for Myocardial Perfusion Imaging on Blood Glucose Concentration; A Preliminary Study

Khorasanchi, Amirreza and Arabi, Mohsen and Seyedabadi, Mohammad and Eftekha, Mansooreh and Javadi, Hamid and Nabipour, Iraj and Assadi, Majid (2016) Effect of Dipyridamole Injected for Myocardial Perfusion Imaging on Blood Glucose Concentration; A Preliminary Study. J Clin Diagn Res.

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Abstract

Abstract INTRODUCTION: Dipyridamole inhibits adenosine reuptake and increases cyclic Adenosine Monophosphate (cAMP) levels in platelets, erythrocytes and endothelial cells, all of which influence blood glucose. Acute hyperglycaemia reduces endothelium-dependent vasodilation and suppresses coronary microcirculation; which, in theory, can alter the outcome of a radionuclide scan. AIM: The present study was conducted with the aim to investigate the changes in blood glucose level of patients receiving dipyridamole for cardiac scan. MATERIALS AND METHODS: A total of 293 patients (85 men and 208 women, age: 60.59±10.43 years) were included in the study. Fasting Blood Glucose (FBG) was measured before and 8 min after dipyridamole (0.568 mg/kg) injection during myocardial perfusion imaging. The data in different groups were analysed by paired t-test. RESULTS: There was not a significant difference between first (106.89 ± 19.21mg/dL) and second (107.98 ± 17.57 mg/dL) FBG measurements (p= 0.293). However, when the patients were grouped based on the quartiles of first measurement, there was an increase in FBG following dipyridamole injection in the first quartile (mean difference: 7.15±21.27 mg/dL, p<0.01); in contrast, FBG levels showed a significant decrease after dipyridamole administration in the 4(th) quartile (mean difference: -9.53±18.20 mg/dL, p<0.001). The differences in 2(nd) and 3(rd) quartiles were negligible. The patients were divided into normal, ischemic and fixed lesions based on the outcome of scans, then the possible correlation of dipyridamole-induced FBG alteration and scan results were investigated. There were no significant difference between the FBG values before and after dipyridamole injection and the final outcome of scan. CONCLUSION: The effects of dipyridamole on blood glucose highly depend on the initial blood glucose level. KEYWORDS: Blood glucose; Dipyridamole; Myocardial perfusion imaging

Item Type: Article
Subjects: WK Endocrine System
Divisions: Faculty of Medicin
Depositing User: محسن زارعی
Date Deposited: 02 Jul 2018 08:55
Last Modified: 02 Jul 2018 08:55
URI: http://eprints.bpums.ac.ir/id/eprint/6043

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