Assadi, Majid and Nabipour, Iraj and Dobaradaran, Sina and Raeisi, Alireza and darabi, hossein and Ostovar, Afshin and Kalantarhormozi, Mohammadreza and Akbarzadeh, Samad and momeni, safieh and Vahdat, Katayoun (2017) The correlation between insulin-like growth factor 1 (IGF-1) and novel adipocytokines in postmenopausal women: A population-based study. Endocrine Research. pp. 1-7. ISSN 0743-5800
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6- The correlation between insulin-like growth factor 1 (IGF-1) and novel adipocytokines in postmenopausal women A population-based study.pdf Download (844kB) | Preview |
Abstract
The adipocytokines and insulin-like growth factor 1 (IGF-1) are involved in insulin resistance, the cardiometabolic syndrome, and atherosclerosis. Therefore, investigating the relationship between circulating levels of the novel adipocytokines and IGF-1 is worthwhile. The correlation between IGF-1, visfatin, and omentin-1 has not been adequately investigated. In a population-based study, 324 postmenopausal women were randomly selected. Circulating IGF-1, visfatin, omentin-1, adiponectin, and high-sensitivity C-reactive protein (hs-CRP) levels weremeasured with the highly specific enzyme-linked immunosorbent assay method. In multiple regression analyses adjusted for alkaline phosphatase, osteocalcin, and hs-CRP, circulating IGF-1 was significantly correlated with visfatin levels (standardized β coefficient [β] = 0.13, partial correlation coefficient [r] = 0.12, p = 0.028). The significant positive correlation between serum IGF-1 and visfatin levels remained after additional adjustments for age and BMI (β = 0.12, r = 0.12, p = 0.025), metabolic syndrome (β = 0.13, r = 0.12, p = 0.021), and type 2 diabetes mellitus (β = 0.13, r = 0.12, p = 0.026). No significant correlationswere found between IGF-1, adiponectin, and omentin-1. There is a significant correlation between serum IGF-1 and visfatin levels in postmenopausalwomen beyondmetabolic syndrome, type 2 diabetes, bone formationmarkers, and hs-CRP levels. The observed correlation between higher circulating IGF-1 and the higher visfatin levels might be a physiological compensation and adaptation to protect against visfatin-induced proinflammatory effects.
| Item Type: | Article |
|---|---|
| Subjects: | WK Endocrine System |
| Divisions: | Research Center > Persian Gulf Nuclear Medicine Research Center |
| Depositing User: | محسن زارعی |
| Date Deposited: | 02 Jul 2018 08:57 |
| Last Modified: | 02 Jul 2018 08:57 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/6137 |
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