The correlation between insulin-like growth factor 1 (IGF-1) and novel adipocytokines in postmenopausal women: A population-based study

Darabia, Hossein and Ostovara, Afshin and Raeisia, Alireza and Kalantarhormozia, Mohammad Reza and Assadib, Majid and Akbarzadeha, Samad and Momenic, Safieh and Dobaradaranc, Sina and Vahdata, Katayoun and Nabipoura, Iraj (2017) The correlation between insulin-like growth factor 1 (IGF-1) and novel adipocytokines in postmenopausal women: A population-based study. Endocrine Research. pp. 1-7.

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Abstract

The adipocytokines and insulin-like growth factor 1 (IGF-1) are involved in insulin resistance, the cardiometabolic syndrome, and atherosclerosis. Therefore, investigating the relationship between circulating levels of the novel adipocytokines and IGF-1 is worthwhile. The correlation between IGF-1, visfatin, and omentin-1 has not been adequately investigated. In a population-based study, 324 postmenopausal women were randomly selected. Circulating IGF-1, visfatin, omentin-1, adiponectin, and high-sensitivity C-reactive protein (hs-CRP) levels weremeasured with the highly specific enzyme-linked immunosorbent assay method. In multiple regression analyses adjusted for alkaline phosphatase, osteocalcin, and hs-CRP, circulating IGF-1 was significantly correlated with visfatin levels (standardized β coefficient [β] = 0.13, partial correlation coefficient [r] = 0.12, p = 0.028). The significant positive correlation between serum IGF-1 and visfatin levels remained after additional adjustments for age and BMI (β = 0.12, r = 0.12, p = 0.025), metabolic syndrome (β = 0.13, r = 0.12, p = 0.021), and type 2 diabetes mellitus (β = 0.13, r = 0.12, p = 0.026). No significant correlationswere found between IGF-1, adiponectin, and omentin-1. There is a significant correlation between serum IGF-1 and visfatin levels in postmenopausalwomen beyondmetabolic syndrome, type 2 diabetes, bone formationmarkers, and hs-CRP levels. The observed correlation between higher circulating IGF-1 and the higher visfatin levels might be a physiological compensation and adaptation to protect against visfatin-induced proinflammatory effects.

Item Type: Article
Subjects: WQ Obstetrics
Divisions: Faculty of Nursing & Midwifery
Depositing User: سپیده مقدسی
Date Deposited: 03 Jul 2018 08:15
Last Modified: 03 Jul 2018 08:15
URI: http://eprints.bpums.ac.ir/id/eprint/6170

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