Yousefinejad, Abbas and Ramezani, Atena and Koohdani, Fariba and Djazayeri, Abolghasem and Nematipour, Ebrahim and Keshavarz, Seyed Ali and Saboor-Yaraghi, Ali-Akbar and Eshraghian, Mohammad-Reza and Javanbakht, Hassan and Zarei, Mahnaz and Gholamhosseini, Sanaz and Djalali, Mahmoud (2015) Effects of administration of omega-3 fatty acids with or without vitamin E supplementation on adiponectin gene expression in PBMCs and serum adiponectin and adipocyte fatty acid-binding protein levels in male patients with CAD. Anatol J Cardiol. pp. 981-989.
|
Text
AJC-15-981.pdf Download (122kB) | Preview |
Abstract
Objective: Adiponectin is a unique anti-atherogenic adipocytokine. Regulation of adiponectin secretion is dysfunctional in cardiovascular diseases. The current trial study assessed the effects of omega-3 fatty acids with or without vitamin E on adiponectin gene expression in peripheral blood mononuclear cells and serum adiponectin and adipocyte fatty acid-binding protein (A-FABP; also called ap2 and FABP4) levels in patients with coronary artery disease (CAD). Methods: This randomized, double-blind, placebo-controlled trial included 67 male patients with CAD. First of the four group of participants received 4 g/day omega-3 fatty acids plus 400 IU/day vitamin E (OE), second group 4 g/day omega-3 fatty acids plus vitamin E placebo (OP), or both omega-3 fatty acid and vitamin E placebos (PP) for 8 weeks. Adiponectin gene expression and serum adiponectin and FABP4 levels were evaluated. Results: The combination of omega-3 fatty acids and vitamin E in patients with CAD affected their serum adiponectin and FABP4 levels and the adiponectin/FABP4 ratio significantly. In the OP group, serum adiponectin levels did not change significantly. Consumption of omega-3 fatty acids with and without vitamin E had no significant effect on adiponectin gene expression. Conclusion: Omega-3 fatty acids with or without vitamin E improve adiponectin levels in patients, without any significant changes in adiponectin gene expression. This nutritional intervention may prevent complications in patients with CAD because of increased adiponectin levels. (Anatol J Cardiol 2015; 15: 981-9)
| Item Type: | Article |
|---|---|
| Subjects: | QU Biochemistry |
| Divisions: | Faculty of Medicin > Department of Biochemistry |
| Depositing User: | سپیده مقدسی |
| Date Deposited: | 03 Jul 2018 08:16 |
| Last Modified: | 03 Jul 2018 08:16 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/6213 |
Actions (login required)
 |
View Item |
