Nabipour, Iraj and Larijani, Bagher and Vahdat, Katayoun and Assadi, Majid and Jafari, Seyed Mojtaba and Ahmadi, Esmaeil and Movahed, Ali and Moradhaseli, Farzad and Sanjdideh, Zahra and Obeidi, Narges and Amiri, Zahra (2009) Relationships among serum receptor of nuclear factor-JB ligand, osteoprotegerin, high-sensitivity C-reactive protein, and bone mineral density in postmenopausal women: osteoimmunity versus osteoinflammatory. The Journal of The North American Menopause Society, 16 (5). pp. 950-955.
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Abstract
Objective: The aim of this study was to investigate the correlations among circulating osteoprotegerin (OPG), the receptor activator of nuclear factor-JB ligand (RANKL), high-sensitivity C-reactive protein (hsCRP), and bone mineral density (BMD) in healthy postmenopausal women. Methods: In a population-based study, highly specific enzyme-linked immunosorbent assay methods were used to evaluate the sera of 382 healthy Iranian postmenopausal women (mean age T SD, 58.7 T 7.5 y) for RANKL, OPG, hsCRP, degradation products of C-terminal telopeptides of type I collagen, and osteocalcin. BMD was determined for the lumbar spine (L2-L4) and the proximal femur using dual-energy x-ray absorptiometry. Results: Circulating levels of OPG (r = 0.30, P G 0.001) and the RANKL/OPG ratio (r = j0.17, P G 0.001) were significantly associated with age. The geometric mean of hsCRP was 1.89 mg/L (SE, 1.05) in the population studied. There was a significant correlation between log(hsCRP) levels and body mass index (BMI; r = 0.36, P G 0.001). Multivariate linear analyses revealed that age (A = j0.295, P G 0.001), BMI (A = 0.464, P G 0.001), RANKL (A = j0.105, P = 0.014), and OPG (A = 0.098, P = 0.029) were the independent determinants for lumbar BMD (R2 = 0.35). Age (A = j0.250, P G 0.001), BMI (A = 0.486, P G 0.001), and RANKL (A = j0.110, P = 0.009) were independently correlated with femoral neck BMD (R2 = 0.36). Age- and BMI-adjusted analysis by quartiles of log-transformed hsCRP did not reveal an association with BMD, serum levels of biochemical markers of bone turnover, RANKL, or OPG. Conclusions: The circulating levels of the RANKL/OPG osteoimmunity system have an association with BMD, but subclinical systemic inflammation may not be involved in bone mass in healthy postmenopausal women.
| Item Type: | Article |
|---|---|
| Subjects: | WP Gynecology |
| Divisions: | Faculty of Medicin |
| Depositing User: | زهرا صفایی |
| Date Deposited: | 03 Jul 2018 08:29 |
| Last Modified: | 03 Jul 2018 08:29 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/6320 |
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