Motamed, Niloofar and Akbarzadeh, Samad and Nabipour, Iraj and Majid, Assadi and Movahed, Ali and Jafari, Seyed Mojtaba and Nazem, Habibollah and Haraghy, Mehrnoosh and Pourbehi, Abdolreza and Bargahi, Afshar and Hajian, Najmeh (2012) The normoglycemic first-degree relatives of patients with type 2 diabetes mellitus have low circulating omentin-1 and adiponectin levels. Cytokine, 58. pp. 295-299.
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8- The normoglycemic first-degree relatives of patients with type 2 diabetes mellitus have low circulating omentin-1 and adiponectin levels.pdf Download (192kB) | Preview |
Abstract
Objective: It has been suggested that adipose-derived cytokines act as insulin sensitizers/insulin-mimetics and some others may induce insulin resistance. In order to elucidate the potential role of novel adipocytokines in the pre-diabetes states, circulating levels of novel adipocytokines were evaluated in first-degree relatives of subjects with type 2 diabetes mellitus (FDRs). Method: Serum omentin-1, adiponectin and retinol-binding protein 4 (RBP4) levels were measured in 179 subjects (90 glucose tolerant FDRs and 89 age- and sex-matched healthy controls) using enzymelinked immunosorbent assay (ELISA) methods. Results: There was no significant difference between the two groups regarding serum RBP4 concentrations. However, serum omentin-1 (median [interquartile range], 6.18 [4.06–11.52] ng/ml versus 10.50 [4.30– 20.60] ng/ml, p = 0.004) and adiponectin (mean ± SD, 10.07 ± 4.0 lg/ml versus 20.66 ± 8.12 lg/ml, p < 0.0001) levels were significantly lower in FDRs when compared with the controls. In multiple logistic regression analysis, FDRs showed a significant association with lower circulating omentin-1 and adiponectin levels, even after adjustments were made for age, sex, body mass index, blood pressure measures, and biochemical parameters including glucose status, lipid profile, insulin levels and HOMA-IR (OR = 0.49, CI [0.30–0.79]; p = 0.004 and OR = 0.74, CI [0.67–0.82]; p < 0.0001, respectively). However, FDRs did not show a significant association with serum RBP4 levels in different models of regression analyses. Conclusions: The FDRs showed significant associations with lower omentin-1 and adiponectin levels. A potential role for these adipokines in the FDRs’ increased risk of diabetes needs to be further elucidated
| Item Type: | Article |
|---|---|
| Subjects: | QU Biochemistry |
| Divisions: | Faculty of Medicin > Department of Social Medicine |
| Depositing User: | محسن زارعی |
| Date Deposited: | 02 Jul 2018 09:00 |
| Last Modified: | 02 Jul 2018 09:00 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/6330 |
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