Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Ostovar, Afshin and Tohidi, Maasumeh and Akbarzadeh, Samad and Larijani, Bagher and Kalantarhormozi, Mohammadreza and Assadi, Majid and Vahdat, katayoun and Farrokhnia, Maryam and Sanjdideh, Zahra and Amirinejad, Roya and Nabipour, Iraj Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women. Bone, 51.


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The bone and fat interface is implicated in the pathogenesis of postmenopausal osteoporosis. The association between circulating omentin-1 levels and bonemineral density (BMD) in postmenopausal women has never been assessed. A total of 382 healthy postmenopausal womenwere randomly selected. Omentin-1, visfatin, adiponectin, the receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin, high sensitivity C-reactive protein, degradation products of C-terminal telopeptides of type I collagen, and osteocalcin were measured by highly specific enzyme-linked immunosorbent assay methods. BMDwas determined for the lumbar spine (L2–L4) and the proximal femur using dual-energy X-ray absorptiometry. In multivariable-adjusted linear regression, serum omentin-1 levels were inversely correlated with BMD at the lumbar spine (β=−0.11, p=0.020). In multiple regression analyses, serum visfatin and adiponectin levels were not significantly correlated with BMD at different skeletal sites after controlling for age, body mass index, and bone-related markers. However, the highest quartile of adiponectin compared to the lowest quartile, after adjusting for potential confounders, revealed an inverse association with BMD in the lumbar spine (β=−0.19, p=0.010). In conclusion, circulating omentin-1 levels had an inverse correlation with BMD at the lumbar spine in Iranian postmenopausal women. To further understand the role of omentin-1 in bone and mineral metabolism, large-scale longitudinal studies focusing on BMD and osteoporotic fractures are warranted

Item Type: Article
Subjects: WE Musculoskeletal system
Divisions: Faculty of Medicin > Department of Social Medicine
Depositing User: محسن زارعی
Date Deposited: 03 Jul 2018 02:15
Last Modified: 03 Jul 2018 02:15

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