The correlation of CD19 + CD24 + CD38 + B cells and other clinicopathological variables with the proportion of circulating Tregs in breast cancer patients

Ostovar, Afshin and Gheybi, Mohammad Kazzem and Farrokhi, Shokrollah and Ravanbod, Mohammad Reza and Mehrzad, Valiollah and Nematollahi, Pardis (2017) The correlation of CD19 + CD24 + CD38 + B cells and other clinicopathological variables with the proportion of circulating Tregs in breast cancer patients. Breast cancer (Tokyo, Japan), 24 (6). ISSN 1340-6868 (Print)

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Abstract

Background T regulatory cells (Tregs) are known to negatively control immune response. The frequency of these cells was inversely correlated with clinical outcomes of breast cancer. CD19?CD24hiCD38hi cells also play a critical role in inflammation and autoimmune disease. However, their function in tumor immune response is less studied. In this study we aimed to determine the role of CD19?CD24hiCD38hi cells and some other clinicopathological variables in increasing the proportion of Tregs in breast cancer patients. Methods We selected 47 patients with invasive ductal breast carcinoma and 50 healthy controls and obtained their blood samples. Results The proportion of circulating CD4?CD25?Foxp3? Tregs and CD19?CD24hiCD38hi cells was significantly increased in breast cancer patients. We also found that increased proportion of Tregs in breast cancer is correlated with HER2 amplification, advanced clinical stages, serum TGF-b1 and increased CD19?CD24hiCD38hi cells in the peripheral blood. Conclusion Altogether, our data suggest that as much as Tregs, CD19?CD24hiCD38hi B cells could also have a part in the suppression of immune response in breast cancer. Keywords Breast cancer T regulatory cells CD19 ? CD24 ? CD38 ? B cells Clinicopathological variables

Item Type: Article
Subjects: WH Hemic and Lymphatic System
Divisions: Faculty of Medicin > Department of Social Medicine
Depositing User: محسن زارعی
Date Deposited: 03 Jul 2018 02:17
Last Modified: 03 Jul 2018 02:17
URI: http://eprints.bpums.ac.ir/id/eprint/6492

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