Rahmani, elham and Badehnoosh, Bita and Karamali, Maryam and Zarrat, Mitra and Jamilian, Mehri and Bahmani, Fereshteh and Tajabadi-Ebrahimi, Maryam and Jafari, Parvaneh and Asemi, Zatollah (2017) The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. The Journal of Maternal-Fetal & Neonatal Medicine. ISSN 1476-7058
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Abstract
Objective: This study was designed to evaluate the effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes among subjects with gestational diabetes (GDM). Methods: This randomized, double-blind, placebo-controlled clinical trial was done among 60 subjects with GDM who were not on oral hypoglycemic agents. Patients were randomly allocated to intake either probiotic capsule containing Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium bifidum (2×109 CFU/g each) (n=30) or placebo (n=30) for 6 weeks. Results: Compared with the placebo, probiotic supplementation resulted in significant decreases in fasting plasma glucose (FPG) (-5.3±6.7 vs. +0.03±9.0 mg/dL, P=0.01), serum high-sensitivity C-reactive protein (hs-CRP) (-2.2±2.7 vs. +0.5±2.4 μg/mL, P<0.001), plasma malondialdehyde (MDA) concentrations (-0.1±0.8 vs. +0.5±1.5 μmol/L, P=0.03) and MDA/TAC ratio (-0.0003±0.0008 vs. +0.0009±0.002, P=0.004), and a significant increase in total antioxidant capacity (TAC) levels (+65.4±103.3 vs. -37.2±143.7 mmol/L, P=0.002). Probiotic supplementation did not affect pregnancy outcomes. Conclusions: Overall, probiotic supplementation among women with GDM for 6 weeks had beneficial effects on FPG, serum hs- CRP, plasma TAC, MDA and oxidative stress index, but did not affect pregnancy outcomes.
| Item Type: | Article |
|---|---|
| Subjects: | WP Gynecology |
| Divisions: | Faculty of Medicin |
| Depositing User: | محسن زارعی |
| Date Deposited: | 03 Jul 2018 02:18 |
| Last Modified: | 03 Jul 2018 02:18 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/6501 |
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