Bargahi, Afshar and Aryapour, Hassan and Dehdab, Maryam and Sohraby, Farzin (2017) Prediction of new chromene-based inhibitors of tubulin using structure-based virtual screening and molecular dynamics simulation methods. Computational biology and chemistry, 71. ISSN 1476-9271 (Print)
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Abstract
Multidrug resistance (MDR) is one of the serious problems in cancer research that causes failure in chemotherapy. Chromene-based compounds have been proven to be the novel anti-MDR agents for inhibiting proliferation of tumor cells through tubulin polymerization inhibition of by binding at the colchicine binding site. In this study, we screened a chromene-based database of small molecules using physicochemical, ADMET properties and molecular docking to identify potential hit compounds. In order to validate our hit compounds, molecular dynamics simulations and related analysis were carried out and the results suggest that our hit compounds (PubChem CIDs: 16814409, 17594471, 57367244 and 69899719) can prove to be potential inhibitors of tubulin. The in silico results show that the present hits, like colchicine, effectively suppressed the dynamic instability of microtubules and induced microtubuledepolymerization and cell cycle arrest.
| Item Type: | Article |
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| Subjects: | QU Biochemistry |
| Divisions: | Faculty of Medicin > Department of Biochemistry |
| Depositing User: | محسن زارعی |
| Date Deposited: | 03 Jul 2018 02:18 |
| Last Modified: | 03 Jul 2018 02:18 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/6511 |
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