Farrokhi, Shokrollah and Gheybi, Mohammad Kazzem and Movahed, Ali and Dehdari, Reyhaneh and Amiri, Shahram and Khazaei, Hossein Ali and Gooya, Mostafa and Dehbashi, Fereshteh and Fatemi, Atena and Sovid, Neda and Hajiani, Gholamreza and Tahmasebi, Rahim and Dobaradaran, Sina and Assadi, Majid (2014) Dusty Air Pollution is Associated with an Increased Risk of Allergic Diseases in Southwestern Part of Iran. Iran J Allergy Asthma Immunol, 13 (6).
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Abstract
Concerns have been raised about the adverse impact of dusty air pollution (DAP) on human health. The aim of this study was to find the association between dusty air pollution based on air quality index (AQI) and the risk of allergic diseases in southwestern provinces of Iran, with assessing cytokine profiles and lymphocyte immunophenotypes. In this case control study 148 individuals participated. The sampling was done in hazardous condition (AQI >300) as the case and clean air (AQI <50) as the control. We measured cytokine production by using ELISA method and phenotypes of T-lymphocytes (CD4+ and CD8+), CD19+ B-lymphocytes, CD25+, CD4+ CD25+ cells by FACSort flow cytometer. The mean serum level of IL-4 (33.4±2.9 vs 0.85± 0.65 pg/dl) and IL-13 (15.1±4.4 vs. 0.12±0.7 pg/dl) in the subjects exposed to ambient DAP was increased significantly compared to the individuals in the clean air condition. Also, CD19+ B-lymphocytes (12.6± 4.9 vs 8.9±3.2%) and CD4+ CD25+ cell count (13.6± 4.6 vs 7.7± 3.8%) in peripheral blood were increased significantly in subjects exposed to ambient DAP compared with the controls. The result of our study suggested that ambient DAP affected immune system in a way that might lead to allergic diseases in the population. Keywords: Allergy; Dusty air pollution; Immune system
| Item Type: | Article |
|---|---|
| Subjects: | WF Respiratory System |
| Divisions: | Faculty of Medicin > Department of Immunology and Allergy |
| Depositing User: | محسن زارعی |
| Date Deposited: | 03 Jul 2018 02:19 |
| Last Modified: | 03 Jul 2018 02:19 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/6528 |
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