TLR9-based immunotherapy for the treatment of allergic diseases

Farrokhi, Shokrollah and Abbasirad, Narjes and Movahed, Ali and Khazaei, Hossein Ali and Pishjoo, Masoud and Rezaei, Nima (2017) TLR9-based immunotherapy for the treatment of allergic diseases. Immunotherapy, 9 (4).

Immunotherapy Volume 9 issue 4 2017 [doi 10.2217%2Fimt-2016-0104] Farrokhi, Shokrollah; Abbasirad, Narjes; Movahed, Ali; Khazaei, -- TLR9-based immunotherapy for the treatment of allergic diseases.pdf

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Toll-like receptors (TLRs), a family of pattern recognition receptors expressed on many cell types of innate immunity, recognize the pathogen-associated molecular patterns of microbes. The hygiene hypothesis suggests that a reduced microbial exposure in early childhood increases the susceptibility to allergic diseases due to deviation in development of the immune system. TLRs are key roles in the right and healthy direction of adaptive immunity with the induction of T-helper 2 toward Th1 immune responses and regulatory T cells. TLR ligand CpG-ODN-based immunomodulation is independent of allergen and it mainly affects innate immune system. While, CpG-oligodeoxynucleotide-based vaccination is allergen specific and induces adaptive immune system. The use of agonists of TLR9 in two distinct strategies of immunotherapy, immunomodulation and vaccination, could be presented as the curative method for the treatment of allergic diseases. First draft submitted: 29 August 2016; Accepted for publication: 8 February 2017; Published online: 17 March 2017 Keywords:  allergic diseases • immunotherapy • TLR9 • Toll-like receptors

Item Type: Article
Subjects: WF Respiratory System
Divisions: Faculty of Medicin > Department of Immunology and Allergy
Depositing User: محسن زارعی
Date Deposited: 03 Jul 2018 02:20
Last Modified: 03 Jul 2018 02:20

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