MOGHADAS JAFARI, Ali and YOUSEFIFARD, M and RAHIMI-MOVAGHAR, V and NASIRINEZHAD, F and BAIKPOUR, M and SAFARI, S and SAADAT, S and ASADY, H and RAZAVI TOUSI, S.M.T and HOSSEINI, M (2016) NEURAL STEM/PROGENITOR CELL TRANSPLANTATION FOR SPINAL CORD INJURY TREATMENT; A SYSTEMATIC REVIEW AND META-ANALYSIS. Neuroscience, 322.
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Abstract
—Despite the vast improvements of cell therapy in spinal cord injury treatment, no optimum protocol has been developed for application of neural stem/progenitor cells. In this regard, the present meta-analysis showed that the effi- cacy of the neural stem/progenitor cell (NSPC) transplantation depends mainly on injury model, intervention phase, transplanted cell count, immunosuppressive use, and probably stem cell source. Improved functional recovery post NSPC transplantation was found to be higher in transection and contusion models. Moreover, NSPC transplantation in acute phase of spinal injury was found to have better functional recovery. Higher doses (>3 � 106 cell/kg) were also shown to be optimum for transplantation, but immunosuppressive agent administration negatively affected the motor function recovery. Scaffold use in NSPC transplantation could also effectively raise functional recovery. � 2016 Published by Elsevier Ltd. on behalf of IBRO
| Item Type: | Article |
|---|---|
| Subjects: | QT Physiology |
| Divisions: | Faculty of Medicin |
| Depositing User: | محسن زارعی |
| Date Deposited: | 03 Jul 2018 02:20 |
| Last Modified: | 03 Jul 2018 02:20 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/6581 |
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