Sensing of Alzheimer’s Disease and Multiple Sclerosis Using Nano-Bio Interfaces

Hajipoura, Mohammad Javad and Ghasemid, Forough and Aghaverdib, Haniyeh and Raoufib, Mohammad and Linne, Uwe and Atyabi, Fatemeh and Nabipour, Iraj and Azhdarzadeh, Morteza and Derakhshankhah, Hossein and Lotfabadi, Alireza and Bargahi, Afshar and Alekhamis, Zahra and Aghaie, Afsaneh and Hashemi, Ehsan and Tafakhori, Abbas and Aghamollaii, Vajiheh and Maserat Mashhadi, Marzie and Sheibani, Sara and Vali, Hojatollah and Mahmoudi, Morteza (2017) Sensing of Alzheimer’s Disease and Multiple Sclerosis Using Nano-Bio Interfaces. Journal of Alzheimer's disease : JAD, 59 (4).

Journal of Alzheimer's Disease Volume 59 issue 4 2017 [doi 10.3233%2FJAD-160206] Hajipour, Mohammad Javad; Ghasemi, Forough; Aghaverdi, Haniyeh; -- Sensing of Alzheimer’s Disease and Multiple Sclerosi (3).pdf

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It is well understood that patients with different diseases may have a variety of specific proteins (e.g., type, amount, and configuration) in their plasmas. When nanoparticles (NPs) are exposed to these plasmas, the resulting coronas may incorporate some of the disease-specific proteins. Using gold (Au) NPs with different surface properties and corona composition, we have developed a technology for the discrimination and detection of two neurodegenerative diseases, Alzheimer's disease (AD) and multiple sclerosis (MS). Applying a variety of techniques, including UV-visible spectra, colorimetric response analyses and liquid chromatography-tandem mass spectrometry, we found the corona-NP complexes, obtained from different human serums, had distinct protein composition, including some specific proteins that are known as AD and MS biomarkers. The colorimetric responses, analyzed by chemometrics and statistical methods, demonstrate promising capabilities of the technology to unambiguously identify and discriminate AD and MS. The developed colorimetric technology might enable a simple, inexpensive and rapid detection/discrimination of neurodegenerative diseases. KEYWORDS: Alzheimer’s disease; colorimetric technology; disease-specific protein corona; gold nanoparticles; multiple sclerosis

Item Type: Article
Subjects: QT Physiology
Divisions: Faculty of Medicin > Department of Biochemistry
Depositing User: محسن زارعی
Date Deposited: 02 Jul 2018 07:05
Last Modified: 02 Jul 2018 07:05

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