, Akbarzadeh, S and Yazdekhasti, N and Najafpour Boushehri, S and Yusof, RM and Nasir Mohammad Taib, M and Mirzaei, K (2012) Effect of vitamin supplementation on serum oxidized low-density lipoprotein levels in male subjects with cardiovascular disease risk factors. Iran J Basic Med Sci., 15 (4).
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Abstract
OBJECTIVE(S): Oxidized low-density lipoproteins (ox-LDLs) appear to play a significant role in atherogenesis. In fact, circulating ox-LDL concentrations have been recognized as a risk factor for cardiovascular disease (CVD). The main objectives of this study were to assess the effects of antioxidant vitamins on ox-LDL as a biomarker of CVD in male subjects with CVD risk factors. MATERIALS AND METHODS: The effect of antioxidant vitamins on ox-LDL as a biomarker of CVD in male subjects with CVD in male subjects with CVD risk factors at baseline and after 12 weeks of supplementation with vitamin E (400 IU), C (500 mg), ß-carotene (15 mg), and the combined supplements (E, C, and ß-carotene) respectively defined as group E, C, B and control group was considered as group P. RESULTS: The mean values for ox-LDL at the baseline were 86.93 ± 26.30 U/l in group C, 94.52 ± 38.40 U/l in group E, 79.73±2.07 U/l in group B, 85.97±23.07 U/l in combined group, and 84.90± 14.66 U/l in group P. After 12 weeks of intervention the percentage of changes for group C, group E, group B, COM group, and group P were (-18.32), (-2286), (-17.31), (-19.01) and (-2.0), respectively. Using Wilcoxon method, significant differences were detected in the mean ox-LDL concentrations of baseline and after intervention, values in the C, E, B and combined groups (P< 005). CONCLUSION: This study illustrated that diet supplemented with vitamin C (500 mg), vitamin E (400 IU), ß-carotene (15 mg), and the combination of these vitamins was associated with lower serum ox-LDL levels. KEYWORDS: Cardiovascular Diseases; Oxidized Low-Density Lipoprotein; Vitamin C; Vitamin E; ß-carotene
| Item Type: | Article |
|---|---|
| Subjects: | WG Cardiovascular System |
| Divisions: | Faculty of Medicin > Department of Biochemistry |
| Depositing User: | زهرا صفایی |
| Date Deposited: | 03 Jul 2018 08:36 |
| Last Modified: | 03 Jul 2018 08:36 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/6668 |
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