Jafari, Seyed Mojtaba and Akbarzadeh, Samad and Nabipour, Iraj and Movahed, Ali and Motamed, Niloofar and Assadi, Majid and Hajian, Najmeh (2012) Serum visfatin and vaspin levels in normoglycemic first-degree relatives of Iranian patients with type 2 diabetes mellitus. Diabetes Research and Clinical Practice.
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Abstract
Aim: To investigate circulating visfatin and vaspin levels in first-degree relatives of subjects with type 2 diabetes mellitus (FDRs) who frequently have higher value of HOMA-IR and beta cell dysfunction. Methods: Serum visfatin and vaspin concentrations were measured in 179 Iranian subjects (90 normoglycemic FDRs and 89 age- and sex-matched healthy controls) using enzymelinked immunosorbent assay (ELISA) methods. Result: Serum visfatin levels were significantly lower in the FDRs when compared to the controls (1.71 � 0.93 ng/ml versus 2.69 � 2.02 ng/ml, p = 0.0001). However, no significant difference was found in serum vaspin concentrations between the FDRs and the controls (0.452 � 0.254 ng/ml versus 0.409 � 0.275 ng/ml, p > 0.05). In multiple logistic regression analysis, the FDRs showed a significant association with lower visfatin levels after adjustments for age, sex, Body Mass Index, systolic and diastolic blood pressures, lipid profile, blood glucose levels and HOMA-IR [odds ratios (OR) = 1.71, 95% confidence interval (1.30–2.25); p < 0.0001]. Conclusion: The FDRs showed a significant association with lower visfatin levels. The observed lower circulating visfatin levels in FDRs may suggest a pathophysiological role for visfatin in beta cell dysfunction in this group.
| Item Type: | Article |
|---|---|
| Subjects: | WK Endocrine System |
| Divisions: | Faculty of Medicin |
| Depositing User: | زهرا صفایی |
| Date Deposited: | 03 Jul 2018 08:36 |
| Last Modified: | 03 Jul 2018 08:36 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/6698 |
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