Oleuropein attenuates the progression of heart failure in rats by antioxidant and antiinflammatory effects

Janahmadi, Zeinab and Nekooeian, Ali Akbar and Moaref, Ali Reza and Emamghoreishi, Masoomeh (2017) Oleuropein attenuates the progression of heart failure in rats by antioxidant and antiinflammatory effects. Naunyn-Schmiedeberg's Arch Pharmacol.

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Abstract

Abstract Much of the beneficial effects of olive products have been attributed to oleuropein. This study examined the effects of oleuropein in rats with heart failure induced by permanent ligation of left coronary arteries. Twenty-four hours after the operation, the rats were assigned to five groups including a sham assigned to receive vehicle (1 ml/day) and four coronary ligated groups assigned to receive vehicle or oleuropein at 5, 10, or 20 mg/kg/day. Five weeks later, echocardiographic and hemodynamic parameters, serum concentrations of oxidative stress, and inflammatory markers were determined. Myocardial infarction group receiving vehicle showed impaired hemodynamic and echocardiographic parameters as evidenced by decreased left ventricular systolic pressure, rate of rise and decrease of left ventricular pressure, stroke volume, ejection fraction, and cardiac output. In addition, significant reduction in superoxide dismutase and glutathione reductase was observed. Oleuropein treatment prevented the reduction of these variables. Moreover, the group had a significantly higher infarct size and serum malondialdehyde, interleukin-1β, and tumor necrosis factor-α than those of the sham group. Treatment with oleuropein prevented the increase of these variables. The results show that oleuropein attenuates the progression of heart failure, possibly by antioxidative and antiinflammatory effects.

Item Type: Article
Subjects: QV pharmacology
Divisions: Faculty of Medicin > Department of Pharmacology
Depositing User: زهرا صفایی
Date Deposited: 03 Jul 2018 08:40
Last Modified: 03 Jul 2018 08:40
URI: http://eprints.bpums.ac.ir/id/eprint/6717

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