The role of serotonin in memory: interactions with neurotransmitters and downstream signaling

Seyedabadi, Mohammad and Fakhfouri, Gohar and Ramezani, Vahid and Ejtemaei Mehr, Shahram and Rahimian, Reza (2014) The role of serotonin in memory: interactions with neurotransmitters and downstream signaling. Exp Brain Res, 232. pp. 723-738.


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Abstract Serotonin, or 5-hydroxytryptamine (5-HT), is found to be involved in many physiological or pathophysiological processes including cognitive function. Seven distinct receptors (5-HT1–7), each with several subpopulations, have been identified for serotonin, which are different in terms of localization and downstream signaling. Because of the development of selective agonists and antagonists for these receptors as well as transgenic animal models of cognitive disorders, our understanding of the role of serotonergic transmission in learning and memory has improved in recent years. A large body of evidence indicates the interplay between serotonergic transmission and other neurotransmitters including acetylcholine, dopamine, γ-aminobutyric acid (GABA) and glutamate, in the neurobiological control of learning and memory. In addition,there has been an alteration in the density of serotonergic receptors in aging and Alzheimer’s disease, and serotonin modulators are found to alter the process of amyloidogenesis and exert cognitive-enhancing properties. Here, we discuss the serotonin-induced modulation of various systems involved in mnesic function including cholinergic, dopaminergic, GABAergic, glutamatergic transmissions as well as amyloidogenesis and intracellular pathways.

Item Type: Article
Subjects: QV pharmacology
Divisions: Faculty of Medicin > Department of Pharmacology
Depositing User: محسن زارعی
Date Deposited: 02 Jul 2018 07:03
Last Modified: 02 Jul 2018 07:03

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