Abdolahi, Mohammad and Shahbazi-Gahrouei, Daryoush (2013) Superparamagnetic iron oxide-C595: Potential MR imaging contrast agents for ovarian cancer detection. Journal of medical physics, 38 (4). pp. 198-204. ISSN 0971-6203 (Print)
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Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs), have played an important role in the promotion of image contrast in magnetic resonance imaging modality. The objective of present study is describing SPIONs conjugated with C595 monoclonal antibody (mAb) against MUC1-expressing ovarian cancer (OVCAR3) cell. Magnetic resonance imaging parameters of the prepared nanoconjugate was investigated in vitro: characterization, cell toxicity, flow cytometry, Prussian blue staining, and cellular uptake as well as biodistribution and magnetic resonance signal intensities under in vivo conditions were also investigated. Magnetic resonance imaging and biodistribution results showed good tumor accumulation and detection, no cytotoxicity, and potential selective as anti-ovarian cancer. In conclusion, based on the findings SPIONs-C595 nanosized-probe is potentially, a selective ovarian molecular imaging tool. Further subsequent in vivo studies and clinical trials are warranted. Keywords: Flow cytometry, magnetic nanoparticles, magnetic resonance imaging, OVCAR3
| Item Type: | Article |
|---|---|
| Subjects: | WP Gynecology |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Physics |
| Depositing User: | محسن زارعی |
| Date Deposited: | 02 Jul 2018 06:49 |
| Last Modified: | 02 Jul 2018 06:49 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/6728 |
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