Comparison the Effect of Letrozole Versus Medroxy Progesterone Acetate on Premenopausal Patients With Endometrial Hyperplasia: An Randomized clinical trial

Rahmani, Elham and Ahmadi, Shahnaz and Motamed, Niloofar and Safinejad, Fatemeh (2017) Comparison the Effect of Letrozole Versus Medroxy Progesterone Acetate on Premenopausal Patients With Endometrial Hyperplasia: An Randomized clinical trial. Crescent Journal of Medical and Biological Sciences, 4 (3). pp. 99-103. ISSN 2148-9696

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Abstract

Objective: The assessing the effect of letrozole and medroxyprogesterone acetate on women with simple endometrial hyperplasia without atypia in reproductive age. Material and Methods: Eighty patients of Abolfazle clinic in Bushehr with abnormal uterine bleeding and simple endometrial hyperplasia enrolled in this study. The patients were randomized in 2 groups: group A included 40 patients who received 10 mg medroxyprogesterone acetate for 10 days in each month during 3 months and group B included 40 patient that received 2.5 mg letrozole for 3 months. Serial transvaginal sonography and estradiol were checked basically and repeated after 3 months of treatment. Main outcome measures were endometrial thickness and estradiol level in serum. Results: In 2 groups A & B, there were no significant differences in the base variables. The level of estradiol in groups A and B before treatment was similar in the 2 groups. Endometrial thickness in groups A and B was not statistically significant. The difference between these 2 groups from the endometrial thickness reduction viewpoint, is not significant (P value = 0.445). The level of decline estradiol in serum in the groups A&B was significant, Conclusion: Letrozole is an acceptable drug for treatment of simple endometrial hyperplasia especially in the patients who did not tolerate medroxyprogesterone.

Item Type: Article
Subjects: WP Gynecology
Divisions: Faculty of Medicin > Department of Womankind
Depositing User: محسن زارعی
Date Deposited: 02 Jul 2018 07:05
Last Modified: 02 Jul 2018 07:05
URI: http://eprints.bpums.ac.ir/id/eprint/6906

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