Rahmani, E and Jamilian, M and Dadpour, B and Nezami, Z and Vahedpoor, Z and Mahmoodi, S and Aghadavod, E and Taghizadeh, M and Hassan, A.B and Asemi, Z (2018) The effects of fish oil on gene expression in patients with polycystic ovary syndrome. European Journal of Clinical Investigation, 48 (3).
Full text not available from this repository.Abstract
BackgroundThis study was conducted to determine the effects of fish oil administration on gene expression related to insulin, lipid and inflammation in women with polycystic ovary syndrome (PCOS). Materials and methodsThis randomized, double-blind, placebo-controlled trial was conducted among 40 subjects with PCOS, aged 18-40 years. Subjects were randomly allocated into two groups to take either 1000 mg omega-3 fatty acids from fish oil (n = 20) or placebo (n = 20) twice a day for 12 weeks. Gene expression related to insulin, lipid and inflammation was quantified in peripheral blood mononuclear cells (PBMC) of PCOS women with RT-PCR method. ResultsOur study demonstrated that after the 12-week intervention, compared with the placebo, fish oil supplementation upregulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-) (P < .001) in PBMC of subjects with PCOS. In addition, compared to the placebo, taking fish oil supplements downregulated gene expression of interleukin-1 (IL-1) (P = .02) and interleukin-8 (IL-8) (P = .01) in PBMC of subjects with PCOS. We did not observe any significant effect of fish oil supplementation on gene expression of lipoprotein(a) [LP(a)], low-density lipoprotein receptor (LDLR), glucose transporter 1 (GLUT-1), tumour necrosis factor alpha (TNF-) and transforming growth factor beta (TGF-) in PBMC of subjects with PCOS. ConclusionsOverall, fish oil supplementation for 12 weeks to subjects with PCOS significantly improved gene expression of PPAR-, IL-1 and IL-8, but did not influence gene expression of LP(a), LDLR, GLUT-1, TNF- and TGF-.
| Item Type: | Article |
|---|---|
| Subjects: | WP Gynecology |
| Divisions: | Faculty of Medicin > Department of Womankind |
| Depositing User: | محسن زارعی |
| Date Deposited: | 04 Jul 2018 07:56 |
| Last Modified: | 04 Jul 2018 07:56 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/7038 |
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