Gheybi, Mohammad Kazzem and Farrokhi, Shokrollah and Ravanbod, Mohammad Reza and Ostovar, Afshin and Mehrzad, Valiollah and Nematollahi, Pardis (2017) The correlation of CD19 + CD24 + CD38 + B cells and other clinicopathological variables with the proportion of circulating Tregs in breast cancer patients. Breast Cancer, 24 (6). pp. 756-764.
Full text not available from this repository.Abstract
Background: T regulatory cells (Tregs) are known to negatively control immune response. The frequency of these cells was inversely correlated with clinical outcomes of breast cancer. CD19+CD24hiCD38hi cells also play a critical role in inflammation and autoimmune disease. However, their function in tumor immune response is less studied. In this study we aimed to determine the role of CD19+CD24hiCD38hi cells and some other clinicopathological variables in increasing the proportion of Tregs in breast cancer patients. Methods: We selected 47 patients with invasive ductal breast carcinoma and 50 healthy controls and obtained their blood samples. Results: The proportion of circulating CD4+CD25+Foxp3+ Tregs and CD19+CD24hiCD38hi cells was significantly increased in breast cancer patients. We also found that increased proportion of Tregs in breast cancer is correlated with HER2 amplification, advanced clinical stages, serum TGF-β1 and increased CD19+CD24hiCD38hi cells in the peripheral blood. Conclusion: Altogether, our data suggest that as much as Tregs, CD19+CD24hiCD38hi B cells could also have a part in the suppression of immune response in breast cancer.
| Item Type: | Article |
|---|---|
| Subjects: | WD Nutrition Disease and metabolic diseases |
| Divisions: | Research Center > The Persian Gulf Tropical Medicine Research Center |
| Depositing User: | محسن زارعی |
| Date Deposited: | 31 Dec 2018 08:23 |
| Last Modified: | 31 Dec 2018 08:23 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/7311 |
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