Yousefinejad, Abbas and Siassi, Fereydoun and Javanbakht, Mohammad Hassan and Ghaedi, Ehsan and Zarei, Mahnaz and Djalali, Ehsan and Jalali, Mahmoud (2017) Effect of genistein and L-carnitine and their combination on lipid profile and inflammatory cytokines in experimental nephrotic syndrome. Reports of Biochemistry and Molecular Biology, 7 (1). pp. 1-8.
Full text not available from this repository.Abstract
Background: Nephrotic syndrome is a disorder caused by kidney damage that results in severe leakage of protein from blood into urine. Hyperlipidemia is one complication of nephrotic syndrome. L-carnitine and genistein can control cardiovascular diseases by causing changes in lipid metabolism and cytokine production. This study was designed to examine the effects of genistein and L-carnitine on serum lipid and cytokine profiles in experimental nephrotic syndrome. Methods: In this study, 50 male Sprague-Dawley rats were randomly divided into five groups of 10 animals each with similar mean body weights (300±50 g). The five groups were NC (normal-control), PC (patientcontrol), LC (L-carnitine), G (genistein), and LCG (L-carnitine-genistein). Serum HDL-cholesterol (HDL) LDL-cholesterol (LDL), triglyceride, cholesterol, IL-6, and TNF-α were measured. Statistics were analyzed using SPSS 18.0. Results: At the end of the study, of the patient groups, HDL was significantly greater in the LC than in the PC or G groups (P<0.001). LDL was significantly less in the G than in the PC, LC, or LCG groups (P<0.001). Interleukin-6 was significantly greater in the PC than in the LC, G, or LCG groups, and significantly greater in the LC than in the G group. (P<0.001), but no significant differences were found for triglyceride, cholesterol, or TNF-α between the patient groups. Conclusions: Genistein had less effect on HDL and triglyceride levels than LC or LCG. Regarding inflammatory cytokines, genistein and L-carnitine had less effect on TNF-α than on IL-6.
| Item Type: | Article |
|---|---|
| Subjects: | WC Communicable Diseases |
| Divisions: | Faculty of Public Health |
| Depositing User: | محسن زارعی |
| Date Deposited: | 31 Dec 2018 08:28 |
| Last Modified: | 31 Dec 2018 08:28 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/7333 |
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