Protective effects of tropisetron on cerulein-induced acute pancreatitis in mice

Seyedabadi, Mohammad and Rahimian, Reza and Zirak, Mohammad Reza and Keshavarz, Mojtaba and Rashidian, Amir and Kazmi, Sareh and Jafarian, Amir Hossein and Karimi, Gholamreza and Mousavizadeh, Kazem (2017) Protective effects of tropisetron on cerulein-induced acute pancreatitis in mice. Biomedicine and Pharmacotherapy, 93. pp. 589-595.

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Acute pancreatitis (AP) causes morbidity and mortality. The aim of the present study was to investigate the protective effect of tropisetron against AP induced by cerulein. Cerulein (50 μg/kg, 5 doses) was used to induce AP in mice. Six hours after final cerulein injection, animals were decapitated. Hepatic/pancreatic enzymes in the serum, pancreatic content of malondialdehyde (MDA), pro-inflammatory cytokines and myeloperoxidase (MPO) activity were measured. Tropisetron significantly attenuated pancreatic injury markers and decreased the amount of elevated serum amylase, lipase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), MPO activities and pro-inflammatory cytokines levels caused by AP in mice. Tropisetron didn't affect the pancreatic levels of MDA. Our results suggest that tropisetron could attenuate cerulein-induced AP by combating inflammatory signaling. Further clinical studies are needed to confirm its efficacy in patients with AP.

Item Type: Article
Subjects: QV pharmacology
Divisions: Faculty of Medicin > Department of Pharmacology
Depositing User: محسن زارعی
Date Deposited: 31 Dec 2018 08:31
Last Modified: 31 Dec 2018 08:31

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