The first report of two cases of fatal liver injury due to anti-tuberculosis drugs in the presence of alpha-1 antitrypsin deficiency

Maleki, N and Ghobadi,, H and Shahi, JM and Habibzadeh, S (2017) The first report of two cases of fatal liver injury due to anti-tuberculosis drugs in the presence of alpha-1 antitrypsin deficiency. International Journal of Mycobacteriology, 6 (2). pp. 187-190.

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/28559523

Abstract

Tuberculosis (TB) is a major global health problem. Awareness of liver injury due to anti-TB therapy is vital because fulminant hepatic failure is a devastating and often fatal condition without liver transplantation. Here, we report for the first time, two patients of fatal liver injury due to anti-TB drugs in the presence of alpha-1 antitrypsin deficiency. Based on the triad of rapid loss in hepatocyte function, the onset of hepatic encephalopathy, and absence of a prior history of liver disease, the diagnosis of acute liver failure was established. Both patients had low levels of serum alpha-1 antitrypsin, consistent with alpha-1 antitrypsin deficiency. Despite aggressive medical therapy and supportive care, patients developed multi-organ failure and died. It seems measuring the serum levels of alpha 1-antitrypsin before beginning anti-TB therapies is necessary, especially when there is emphysema or bronchiectasis.

Item Type: Article
Subjects: QV pharmacology
Divisions: Research Center > The Persian Gulf Tropical Medicine Research Center
Depositing User: سپیده مقدسی
Date Deposited: 31 Dec 2018 08:51
Last Modified: 31 Dec 2018 08:51
URI: http://eprints.bpums.ac.ir/id/eprint/7378

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