Maleki, N and Ghobadi,, H and Shahi, JM and Habibzadeh, S (2017) The first report of two cases of fatal liver injury due to anti-tuberculosis drugs in the presence of alpha-1 antitrypsin deficiency. International Journal of Mycobacteriology, 6 (2). pp. 187-190.
Full text not available from this repository.Abstract
Tuberculosis (TB) is a major global health problem. Awareness of liver injury due to anti-TB therapy is vital because fulminant hepatic failure is a devastating and often fatal condition without liver transplantation. Here, we report for the first time, two patients of fatal liver injury due to anti-TB drugs in the presence of alpha-1 antitrypsin deficiency. Based on the triad of rapid loss in hepatocyte function, the onset of hepatic encephalopathy, and absence of a prior history of liver disease, the diagnosis of acute liver failure was established. Both patients had low levels of serum alpha-1 antitrypsin, consistent with alpha-1 antitrypsin deficiency. Despite aggressive medical therapy and supportive care, patients developed multi-organ failure and died. It seems measuring the serum levels of alpha 1-antitrypsin before beginning anti-TB therapies is necessary, especially when there is emphysema or bronchiectasis.
| Item Type: | Article |
|---|---|
| Subjects: | QV pharmacology |
| Divisions: | Research Center > The Persian Gulf Tropical Medicine Research Center |
| Depositing User: | سپیده مقدسی |
| Date Deposited: | 31 Dec 2018 08:51 |
| Last Modified: | 31 Dec 2018 08:51 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/7378 |
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