Synthesis of new dihydropyrrol-2-one derivatives bearing sulfonamide groups and studies their antibacterial activity

Gharibi, Marzieh and Niknamd, K. and Bavadi, Masoumeh (2017) Synthesis of new dihydropyrrol-2-one derivatives bearing sulfonamide groups and studies their antibacterial activity. Monatshefte fur Chemie, 148 (6). pp. 1025-1034.

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Official URL: https://link.springer.com/article/10.1007/s00706-0...

Abstract

Abstract: A novel series of dihydropyrrol-2-one compounds bearing sulfonamide groups were synthesized and assayed for in vitro antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Streptococcus epidermidis bacteria. Antibacterial results showed that most of the compounds exhibited the antibacterial activity against P. aeruginosa and S. epidermidis and displayed no inhibition against S. aureus and E. coli. Interestingly, most of the screened compounds were more active than the reference drug trimethoprim-sulfamethoxazole against P. aeruginosa. Among them, one compound exhibited good antibacterial activity in comparison with the reference drugs against P. aeruginosa and may make it as potential an antibacterial agent. Graphical abstract: [Figure not available: see fulltext.].

Item Type: Article
Subjects: QW Microbiology and Immunology
Divisions: Faculty of Medicin > Department of Microbiology
Depositing User: زهرا صفایی
Date Deposited: 31 Dec 2018 08:38
Last Modified: 31 Dec 2018 08:38
URI: http://eprints.bpums.ac.ir/id/eprint/7401

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