Molecular interaction of fibrinogen with zeolite nanoparticles

Nabipour, Iraj and Hajipour, Mohammad Javad and Derakhshankhah, Hossein and Hosseini, Atiyeh and Taghavi, Fereshteh and Jafari, Samira and Lotfabadi, Alireza and Ejtehadi, Mohammad Reza (2019) Molecular interaction of fibrinogen with zeolite nanoparticles. Scientific Reports, 9 (1).

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Fibrinogen is one of the key proteins that participate in the protein corona composition of many types of nanoparticles (NPs), and its conformational changes are crucial for activation of immune systems. Recently, we demonstrated that the fibrinogen highly contributed in the protein corona composition at the surface of zeolite nanoparticles. Therefore, understanding the interaction of fibrinogen with zeolite nanoparticles in more details could shed light of their safe applications in medicine. Thus, we probed the molecular interactions between fibrinogen and zeolite nanoparticles using both experimental and simulation approaches. The results indicated that fibrinogen has a strong and thermodynamically favorable interaction with zeolite nanoparticles in a non-cooperative manner. Additionally, fibrinogen experienced a substantial conformational change in the presence of zeolite nanoparticles through a concentration-dependent manner. Simulation results showed that both E- and D-domain of fibrinogen are bound to the EMT zeolite NPs via strong electrostatic interactions, and undergo structural changes leading to exposing normally buried sequences. D-domain has more contribution in this interaction and the C-terminus of γ chain (γ 377–394 ), located in D-domain, showed the highest level of exposure compared to other sequences/residues.

Item Type: Article
Subjects: QV pharmacology
Divisions: Research Center > Persian Gulf Marine Biotechnology Research Center
Depositing User: محسن زارعی
Date Deposited: 16 Apr 2019 05:24
Last Modified: 16 Apr 2019 05:24

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