CD73 as a potential opportunity for cancer immunotherapy

Hojjat-Farsangi, Mohammad and Ghalamfarsa, Ghasem and Kazemi, Mohammad Hossein and Raoofi Mohseni, Sahar and Masjedi, Ali and Azizi, Gholamreza and Yousefi, Mehdi and Jadidi-Niaragh, Farhad (2019) CD73 as a potential opportunity for cancer immunotherapy. Expert Opinion on Therapeutic Targets, 23 (2). pp. 127-142.

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Introduction: Cancer cells apply various mechanisms to induce and enhance immune escape. The complex network of immune-response modulating factors in the tumor microenvironment is a reason for the difficulties encountered when attempting to treat many cancers. Adenosine is a potent immune-modulating factor that can be generated through the degradation of ATP by cooperative action of NTPDase1 (CD39) and ecto-5ʹ-nucleotidase (CD73) molecules. Overexpression of CD73 on tumor and immune cells leads to the presence of a high concentration of this factor in the tumor region. Upregulation of CD73 is associated with the overproduction of adenosine; it suppresses antitumor immune responses and helps proliferation, angiogenesis, and metastasis. Areas covered: We attempt to clarify the immunobiology of CD73 in association with its role in cancer development, angiogenesis, and metastasis. Moreover, we have reviewed CD73-targeting studies and highlighted CD73 as a potent target for cancer immunotherapy. Expert opinion: It seems that blockade of CD73, in combination with immune checkpoint inhibitors such as anti-PD-L1 and anti-CTLA-4, can be a novel promising therapeutic strategy that can be evaluated in the future trials.

Item Type: Article
Subjects: QW Microbiology and Immunology
Divisions: Faculty of Medicin > Department of Immunology and Allergy
Depositing User: محسن زارعی
Date Deposited: 17 Apr 2019 07:45
Last Modified: 17 Apr 2019 07:45

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