Amyloid fibril inhibition, acceleration, or fragmentation; Are nano-based approaches advance in the right direction?

Hajipour, M.J and Mohammad-Beigi, H and Nabipour, I and Mahmoudi, N and Azhdarzadeh, M and Derakhshankhah, H and Dawud, D.E and Mohammadinejad, R and Otzen, D.E (2020) Amyloid fibril inhibition, acceleration, or fragmentation; Are nano-based approaches advance in the right direction? Nano Today, 35. p. 100983. ISSN 17480132

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Abstract

Nanotechnology-based approaches have shown promising potential to overcome the challenges associated with current therapeutic/diagnostic approaches and offer exciting solutions to improve the quality of life of Alzheimer's Disease (AD) patients. Unfortunately, thus far they have failed in clinical translation. These disappointing results question whether nanotechnology-based therapeutic strategies are heading in the right direction. Here, we re-consider the problems and current therapeutic approaches from new angles and suggest what might have been overlooked in advanced AD therapy.

Item Type: Article
Uncontrolled Keywords: Alzheimer's disease Aβ Fibrillation Nanoparticles Nanotechnology
Subjects: T Technology > TD Environmental technology. Sanitary engineering
Divisions: Research Center > Persian Gulf Marine Biotechnology Research Center
Depositing User: خدیجه شبانکاره
Date Deposited: 20 Dec 2020 09:09
Last Modified: 20 Dec 2020 09:09
URI: http://eprints.bpums.ac.ir/id/eprint/9012

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