Cancer associated fibroblasts as novel promising therapeutic targets in breast cancer

Salimifard, S and Masjedi, A and Hojjat-Farsangi, M and Ghalamfarsa, G and Irandoust, M and Azizi, G and Mohammadi, H and Keramati, M.R and Jadidi-Niaragh, F (2020) Cancer associated fibroblasts as novel promising therapeutic targets in breast cancer. Pathology Research and Practice, 216 (5). p. 152915. ISSN 03440338

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Breast cancer is one of the most important women-related malignancies, which is incurable (particularly in advanced stages) and tumor microenvironment is a number one accused part in the inefficiency of current anti-breast cancer therapeutic strategies. The tumor microenvironment is composed of various cellular and acellular components, which provide an optimum condition for freely expanding cancer cells in various cancer types, particularly breast cancer. Cancer-associated fibroblasts (CAFs) are one of the main cell types in the breast tumor region, which can promote various tumor-promoting processes such as expansion, angiogenesis, metastasis and drug resistance. CAFs directly (by cell-to-cell communication) and indirectly (through secreting soluble factors) can exert their tumorigenic functions. We try to elucidate the immunobiology of CAFs, their origin, function, and heterogeneity in association with their role in various cancer-promoting processes in breast cancer. Based on current knowledge, we believe that the origin of CAFs, their subsets, and their specific expressed biomarkers determine their pro- or anti-tumor functions. Therefore, targeting CAF without considering their specific functions may lead to a deleterious outcome. We propose to find and characterize each subtype of CAFs in association with its specific function in different stages of breast cancer to develop novel promising therapeutic approaches against the right CAF subtype.

Item Type: Article
Uncontrolled Keywords: Breast cancer Cancer associated fibroblast Cancer therapy Fibroblast Tumor microenvironment
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Research Center > Persian Gulf Marine Biotechnology Research Center
Depositing User: خدیجه شبانکاره
Date Deposited: 22 Dec 2020 10:27
Last Modified: 22 Dec 2020 10:27

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