Ababzadeh, S and Farzin, A and Goodarzi, A and Karimi,, R and Sagharjoghi Farahani, M and Eslami Farsani, M and Gharibzad, K and Zahiri, M and Ai, J (2020) High porous electrospun poly(ε-caprolactone)/gelatin/MgO scaffolds preseeded with endometrial stem cells promote tissue regeneration in full-thickness skin wounds: An in vivo study. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 108 (7). pp. 2961-2970. ISSN 1552-4973
Full text not available from this repository.Abstract
In the current study, electrospun poly(ε-caprolactone)-gelatin (PCL-Gel) fibrous scaffolds containing magnesium oxide (MgO) particles and preseeded with human endometrial stem cells (hEnSCs) were developed to use as wound care material in skin tissue engineering applications. Electrospun fibers were fabricated using PCL-Gel (1:1 [wt/wt]) with different concentrations of MgO particles (1, 2, and 4 wt%). The fibrous scaffolds were evaluated regarding their microstructure, mechanical properties, surface wettability, and in vitro and in vivo performances. The full-thickness excisional wound model was used to evaluate the in vivo wound healing ability of the fabricated scaffolds. Our findings confirmed that the wounds covered with PCL-Gel fibrous scaffolds containing 2 wt% MgO and preseeded with hEnSCs have nearly 79% wound closure ability while sterile gauze showed 11% of wound size reduction. Our results can be employed for biomaterials aimed at the healing of full-thickness skin wounds.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | endometrial stem cellsmagnesium oxidePCL electrospun scaffoldskin tissue regeneration |
| Subjects: | WL Nervous system |
| Divisions: | Faculty of Medicin > Department of Neurology |
| Depositing User: | خدیجه شبانکاره |
| Date Deposited: | 22 Dec 2020 08:45 |
| Last Modified: | 22 Dec 2020 08:45 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/9079 |
Actions (login required)
 |
View Item |
