Sheikhi, A and Hojjat-Farsangi, M (2020) An immunotherapeutic method for COVID-19 patients: a soluble ACE2-Anti-CD16 VHH to block SARS-CoV-2 Spike protein. Human Vaccines and Immunotherapeutics. pp. 1-6. ISSN 21645515
Full text not available from this repository.Abstract
The third outbreak of coronavirus (CoV) infection (after SARS-CoV and MERS-CoV) caused by a novel CoV (SARS-CoV-2) of the genus Beta-coronavirus has become a global pandemic. CoVs are enveloped viruses whose proteins include spike (S), membrane (M), and envelope (E) which are embedded in the viral envelope. The glycosylated S protein, which forms homo-trimeric spikes on the surface of the viral particle, mediates viral entry into host cells. SARS-CoV-2, like SARS-CoV, uses the Angiotensin-Converting Enzyme 2 (ACE2) cell surface protein for cellular entry. An attractive anti-viral approach is targeting virus entry into cells, for which three strategies are suggested: 1) direct targeting of the viral glycoprotein; 2) targeting the viral receptor on the cell surface; and 3) using soluble (s) ACE2 that binds to S protein thereby neutralizing the virus. In this article, the advantages and disadvantages of these strategies are explained. Moreover, we propose that fusion of the sACE2 to anti-CD16 to produce a bi-specific molecule could be a promising anti-viral strategy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cd16 COVID-19 sACE2 sACE2-Anti-CD16 sars-CoV-2 |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology QZ Pathology |
| Divisions: | Faculty of Medicin > Department of Immunology and Allergy |
| Depositing User: | خدیجه شبانکاره |
| Date Deposited: | 26 Dec 2020 10:19 |
| Last Modified: | 26 Dec 2020 10:19 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/9104 |
Actions (login required)
 |
View Item |
