Alipour, Z. and Armin, A and Mohamadi, S and Tabib, S.M and Azizmohammadi, Z and Gholamrezanezhad, A.d and Assadi, M (2020) Hepatopulmonary syndrome with right-to-left shunt in cirrhotic patients using macro-aggregated albumin lung perfusion scan: Comparison with contrast echocardiography and association with clinical data [Sirotik hastalardaki sağ-sol şant ile ilişkili hepatopulmoner sendromun tanısında makro-agregant albümin akciğer perfüzyon sintigrafisinin kontrast ekokardiyografi ile karşılaştırılması ve klinik veriler ile ilişkisi]. Molecular Imaging and Radionuclide Therapy, 29 (1). pp. 1-6. ISSN 21461414
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Abstract
Objectives: The diagnosis of hepatopulmonary syndrome (HPS) which is a common complication in cirrhotic patients is still subject to debate. This study investigated the association of clinical findings with HPS in cirrhotic patients using macro-aggregated albumin lung perfusion scan (99mTc-MAA lung scintigraphy). In addition, comparison between99mTc-MAA lung scintigraphy and contrast echocardiography (CEE) in detection of HPS was also performed. Methods: In this study, 27 patients with cirrhosis underwent99mTc-MAA lung scintigraphy and contrast echocardiography comparison CEE and the frequency of HPS was assessed in them and also was compared across the other variables. Results: The99mTc-MAA lung scintigraphy showed HPS in 13 patients (48.1%) while CEE demonstrated HPS in 5 patients with cirrhosis (18.51%). HPS was mild in 40.74% (11/27) of the patients, and severe in only 2 patients. There was no relationship between gender, disease duration, having diagnosis of disease previously, pulmonary symptoms and Child-Pugh score variations and HPS (p>0.05). Comparison of hemodynamic indices, arterial blood gas analysis and laboratory indices between patients with and without HPS was also non-significant (p value >0.05). Among coagulation factors assessed in cirrhotic patients, we found only significant correlation between HPS and prothrombin time (p<0.05). Conclusion: HPS, particularly its mild form, is noted in a great number of patients with cirrhosis using 99mTc-MAA lung scintigraphy. Because of its technical ease, and possibility to obtain objective quantitative information,99mTc-MAA lung scintigraphy can be complementary to other diagnostic methods in the evaluation of HPS assessment, although additional studies are needed.
| Item Type: | Article |
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| Uncontrolled Keywords: | (Cirrhosis) (Contrast echocardiography) (Hepatopulmonary syndrome) (Macro-aggregated albumin lung perfusion scan) |
| Subjects: | WN Radiology . Diagnostic Imaging |
| Divisions: | Research Center > Persian Gulf Nuclear Medicine Research Center |
| Depositing User: | خدیجه شبانکاره |
| Date Deposited: | 26 Dec 2020 08:20 |
| Last Modified: | 26 Dec 2020 08:20 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/9132 |
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