Precision medicine approach in prostate cancer

Assadi, M and Jokar, N and Ghasemi, M and Nabipour, I and Gholamrezanezhad, A and Ahmadzadehfar, H (2020) Precision medicine approach in prostate cancer. Current Pharmaceutical Design, 26 (31). pp. 3783-3798. ISSN 13816128

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Prostate cancer is the most prevalent type of cancer and the second cause of death in men worldwide. Various diagnostic and treatment procedures are available for this type of malignancy, but High-grade or locally advanced prostate cancers showed the potential to develop to lethal phase that can be causing dead. Therefore, new approaches are needed to prolong patients’ survival and to improve their quality of life. Precision medicine is a novel emerging field that plays an essential role in identifying new sub-classifications of diseases and in provid-ing guidance in treatment that is based on individual multi-omics data. Multi-omics approaches include the use of genomics, transcriptomics, proteomics, metabolomics, epigenomics and phenomics data to unravel the complex-ity of a disease-associated biological network, to predict prognostic biomarkers, and to identify new targeted drugs for individual cancer patients. We review the impact of multi-omics data in the framework of systems biology in the era of precision medicine, emphasising the combination of molecular imaging modalities with high-throughput techniques and the new treatments that target metabolic pathways involved in prostate cancer.

Item Type: Article
Uncontrolled Keywords: Castration-resistant prostate cancer, Metabolic net-work, Network analysis, Omics tool, Precision medicine, Prostate biomarker, PSMA Theranostic, Systems biology
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Research Center > Persian Gulf Nuclear Medicine Research Center
Depositing User: خدیجه شبانکاره
Date Deposited: 26 Dec 2020 08:15
Last Modified: 26 Dec 2020 08:15

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