Gholamrezanezhad,, A and Shooli,, H and Jokar,, N. and Nemati,, R and Assadi,, M (2019) Radioimmunotherapy (RIT) in Brain Tumors. Nuclear Medicine and Molecular Imaging, 53 (6). pp. 374-381. ISSN 18693474
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Abstract
Annually, the incidence of brain tumors has slightly increased and also the patient prognosis is still disappointing, especially for high-grade neoplasms. So, researchers seek methods to improve therapeutic index as a critical aim of treatment. One of these new challenging methods is radioimmunotherapy (RIT) that involves recruiting a coupling of radionuclide component with monoclonal antibody (mAb) which are targeted against cell surface tumor–related antigens or antigens of cells within the tumor microenvironment. In the context of cancer care, precision medicine is exemplified by RIT; precision medicine can offer a tailored treatment to meet the needs for treatment of brain tumors. This review aims to discuss the molecular targets used in radioimmunotherapy of brain tumors, available and future radioimmunopharmaceutics, clinical trials of radioimmunotherapy in brain neoplasms, and eventually, conclusion and future perspective of application of radioimmunotherapy in neurooncology cancer care. © 2019, Korean Society of Nuclear Medicine.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Brain tumors،Monoclonal antibody (mAb)،Radioimmunotherapy (RIT) |
| Subjects: | WN Radiology . Diagnostic Imaging |
| Divisions: | Research Center > Persian Gulf Nuclear Medicine Research Center |
| Depositing User: | خدیجه شبانکاره |
| Date Deposited: | 26 Dec 2020 10:12 |
| Last Modified: | 26 Dec 2020 10:12 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/9161 |
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