Impact of SARS-CoV-2 Pandemic on Patients with Primary Immunodeficiency

Shirkani, A and Delavari, S and Abolhassani, H and Abolnezhadian, F and Babaha, F and Iranparast, S and Ahanchian, H (2021) Impact of SARS-CoV-2 Pandemic on Patients with Primary Immunodeficiency. Journal of Clinical Immunology, 41 (2). 345 -355. ISSN 02719142

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Although it is estimated that COVID-19 life-threatening conditions may be diagnosed in less than 1:1000 infected individuals below the age of 50, but the real impact of this pandemic on pediatric patients with different types of primary immunodeficiency (PID) is not elucidated. The current prospective study on a national registry of PID patients showed that with only 1.23 folds higher incidence of infections, these patients present a 10-folds higher mortality rate compared to population mainly in patients with combined immunodeficiency and immune dysregulation. Therefore, further management modalities against COVID-19 should be considered to improve the survival rate in these two PID entities using hematopoietic stem cell transplantation and immunomodulatory agents.

Item Type: Article
Subjects: QW Microbiology and Immunology
Divisions: Faculty of Medicin > Department of Immunology and Allergy
Depositing User: خدیجه شبانکاره
Date Deposited: 04 Jul 2021 08:13
Last Modified: 04 Jul 2021 08:13

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