Zaeri, S and Seyedian, R and Shabankareh Fard, E and Hashemi, S.S and Hasanzadeh, H and Assadi, M (2021) Diltiazem-loaded electrospun nanofibers as a new wound dressing: fabrication, characterization, and experimental wound healing. Pharmaceutical Development and Technology, 26 (2). 167 -180. ISSN 10837450
Full text not available from this repository.Abstract
Calcium channel blockers such as diltiazem have recently been investigated for their wound-healing potential. The aims of this study were to fabricate diltiazem-loaded nanofibers for a new wound dressing and investigate their beneficial properties for wound healing. Nanofibers were electrospun using polyvinyl alcohol solution containing 0, 2 or 4% diltiazem. Fibers were characterized in terms of physicochemical properties, drug release and fibroblast viability, and in animal wound healing assays. Compared to other formulations, nanofibers containing 4% diltiazem showed thin fiber size (152.7 nm), high porosity (88.4%), high swelling (110.4%), low water contact angle (29.1°) and little weight loss (17.3%). Drug release from 4%-diltiazem nanofibers showed good fit to a Korsmeyer–Peppas model, suggesting a non-Fickian release mechanism (R 2 = 96%, n = 0.52). In vitro, 4%-diltiazem mats were not cytotoxic and enhanced fibroblast proliferation by 263% after 5 days of treatment compared to control. In vivo, wounds treated with this mat for 14 days showed the smallest size (14.7%) and better histopathologic characteristics compared to other wounds. The 4%-diltiazem mat also demonstrated significant antioxidant activity by reducing tissue MDA and nitrite levels by 63 and 59% compared to normal saline. The findings support the eligibility of this novel wound dressing for additional clinical research.
| Item Type: | Article |
|---|---|
| Subjects: | QV pharmacology |
| Divisions: | Faculty of Medicin > Department of Pharmacology |
| Depositing User: | خدیجه شبانکاره |
| Date Deposited: | 04 Jul 2021 08:18 |
| Last Modified: | 04 Jul 2021 08:18 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/9368 |
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