Oncostatin M: A mysterious cytokine in cancers

Hojjat-Farsangi, M and Masjedi, A and Hajizadeh, F and Beigi Dargani, F and Beyzai, B (2021) Oncostatin M: A mysterious cytokine in cancers. International Immunopharmacology, 90. ISSN 15675769

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Official URL: https://www.sciencedirect.com/science/article/pii/...


Oncostatin M (OSM), as a member of the Interleukin-6 family cytokines, plays a significant role in inflammation, autoimmunity, and cancers. It is mainly secreted by T lymphocytes, neutrophils, and macrophages and was initially introduced as anti-cancer agent. However, in some cases, it promotes cancer progression. Overexpression of OSM and OSM receptor has been detected in various cancers including colon cancer, breast cancer, pancreatic cancer, myeloma, brain tumors, chronic lymphocytic leukemia, and hepatoblastoma. STAT3 is the main downstream signaling molecule of OSM, which operates the leading role in modifications of cancer cells and enhancing cell growth, invasion, survival, and all other hallmarks of cancer cells. However, due to the presence of multiple signaling pathways, it can act contradictory in some cancers. In this review, we will discuss the emerging roles of OSM in cancer and elucidate its function in tumor control or progression and finally discuss therapeutic approaches designed to manipulate this cytokine in cancer.

Item Type: Article
Subjects: QZ Pathology
Divisions: Research Center > Persian Gulf Marine Biotechnology Research Center
Depositing User: خدیجه شبانکاره
Date Deposited: 04 Sep 2021 06:52
Last Modified: 04 Sep 2021 06:52
URI: http://eprints.bpums.ac.ir/id/eprint/9401

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