Azole antifungal resistance in candida albicans and candida glabrata isolated from vulvovaginal candidiasis patients

Deravi, N and Fathi, M and Tabatabaeifar, S.N and pooransari, P and Ahmadi, B and Shokoohi, G and yaghoobpoor, s and vakilil, k and lotfali, E and Ansari, S (2021) Azole antifungal resistance in candida albicans and candida glabrata isolated from vulvovaginal candidiasis patients. Archives of Clinical Infectious Diseases, 16 (2). ISSN 23452641

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Abstract

Background: Vulvovaginal candidiasis (VVC) is the most frequent fungal disorder in healthy and normal women. Objectives: The aim of this study was to evaluate the in vitro antifungal susceptibility of clinical isolates Candida albicans and Candida glabrata, the two most common candida species in Iranian patients with VVC. Methods: One hundred and eight clinical isolates of candida, including; C. albicans (n = 77) and C. glabrata: (n = 31) were isolated from the 108 patients with VVC. The in vitro activity of caspofungin (CAS), amphotericin B (AMB), voriconazole (VRC), itraconazole (ITC), fluconazole (FLC), and nystatin (NYS) were determined according to the CLSI M27-A3 and CLSI M27-S4. Results: Our results were shown 8 (25.8 %) and 6 (7.8 %) C. glabrata and C. albicans isolates resistance to FLU, respectively. Furthermore, resistance to VRC and ITC were observed in 8.4%, and 3.7% of all isolates, and six isolates (5.6%) had intermediate MIC to CAS. Conclusions: We reported 8 (25.8 %) and 6 (7.8 %) C. glabrata and C. albicans isolates resistance to FLU, respectively. Furthermore, resistance to VRC and ITC were observed in 8.4% and 3.7% of all isolates, respectively. © 2021, Author(s).

Item Type:	Article
Subjects:	QV pharmacology QW Microbiology and Immunology W General Medicine , Health professions
Divisions:	Faculty of Paramedics
Depositing User:	خدیجه شبانکاره
Date Deposited:	13 Nov 2021 08:14
Last Modified:	13 Nov 2021 08:14
URI:	http://eprints.bpums.ac.ir/id/eprint/9436

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